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Awọn ọja

3,3′- diindolylmethane Ifihan Aworan
  • 3,3'- diindolylmethane

3,3'- diindolylmethane

Apejuwe kukuru:

3,3'- diindolylmethane (3,3'-diindolylmethane) jẹ funfun si fere funfun lulú lulú, eyi ti o jẹ tiotuka ni kẹmika, ethyl acetate, dichloromethane ati awọn ohun elo ti o wa ni erupẹ miiran.3,3′- methane diindole wa ni ibigbogbo ni awọn irugbin adayeba ti Cruciferae.O ni awọn iṣẹ iṣe ti ẹkọ ati elegbogi pataki ati pe o lo pupọ ni aaye oogun ati awọn ọja ilera.3,3'-diindolylmethane (DIM) jẹ ọja ounjẹ akọkọ ti indole-3-carbinol, eyiti o jẹ ohun elo anticancer ti o pọju ninu awọn ẹfọ cruciferous.3,3'-diindolylmethane (DIM) jẹ alatako to lagbara ti olugba Android mimọ (AR).

Alaye ọja

ọja Tags

Apejuwe

3,3'-diindolylmethane jẹ agbedemeji elegbogi;O le rii ni awọn phytochemicals adayeba ti o jẹ ti Awọn ohun ọgbin Cruciferae, awọn ọja ifaseyin acid catalyzed, indole-3-methanol;O ni iṣẹ ti aṣoju egboogi-egbogi;Labẹ ipo ti ifọkansi ti o ga julọ, itọsẹ ko le mu iyara taara ti apoptosis ti awọn sẹẹli alakan eniyan, ṣugbọn tun ṣe akiyesi itọpa lati fa apoptosis ti awọn sẹẹli alakan eniyan;Chemicalbookdim nfa idinamọ oruka sẹẹli G1 ni awọn sẹẹli igbaya igbaya eniyan MCF-7 nipasẹ siseto ati ikosile ifisi;Dim jẹ oludena agbara ti mitochondrial h + -atpase;Gẹgẹbi olupolowo idagbasoke ọgbin tuntun, dim ati awọn itọsẹ rẹ ti lo ninu iwadii eto ore-aye.

Alaye ọja

Cas No.. 1968-05-4

Mimọ: ≥98%

Fọọmu: C17H14N2

Fọọmu Wt.: 246.31

Orukọ Kemikali: 3,3'-Diindolylmethane

Itumọ ọrọ: 3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Ọgbin:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE

Oju Iyọ: 167 °C

Oju ibi farabale: 230 °C

Solubility: Chloroform (Sparingly), Methanol (Diẹ)

Irisi: Pa-funfun lulú

Sowo ati Ibi ipamọ

Iduroṣinṣin ibi ipamọ Niyanju ipamọ otutu -20°C.

Igbaradi Ibi indole (1.17 g, 10 mmol), CTAB (50% mol) ati oxalic acid (50% mol) ni 25 milimita kan ti o ni ọrun-ọrun yika-isalẹ, fi omi milimita 5 milimita kun, mu daradara fun iṣẹju 5 ati lẹhinna. fi omi formaldehyde kun (otutu 0.38 g, 5 mmol formaldehyde) dropwise.Fesi fun awọn wakati 3 ni iwọn otutu yara ki o da iṣesi naa duro.Ojutu esi ti fa jade pẹlu milimita 15 ti ethyl acetate ni awọn apakan mẹta, ati pe a gba ipele Organic ati gbigbe pẹlu Na2SO4 anhydrous fun awọn wakati 5.A ti yọ epo kuro labẹ titẹ ti o dinku ati tun ṣe atunṣe lati inu adalu kẹmika ati omi (methanol/H2ChemicalbookO = 10/1) lati fun funfun 3,3'-diindolylmethane ti o lagbara ni 85% ikore.Bioactivity3,3'-Diindolylmethane (DIM) jẹ ọja tito nkan lẹsẹsẹ akọkọ ti indole-3-carbinol, eyiti o jẹ nkan anticancer ti o pọju ninu awọn ẹfọ cruciferous.3,3'-Diindolylmethane (DIM) jẹ antagonist funfun ti o lagbara ti androgenreceptor (AR) .
Awọn ẹkọ inu vitro ti fihan pe DIM jẹ oludabobo redio ti o munadoko ati idinku, ṣiṣe nipasẹ safikun ATM-ìṣó DDR-like awọn idahun bi daradara bi NF-κB iwalaaye ifihan agbara.DIM le dojuti tumo cell ayabo, angiogenesis, afikun ati fa apoptosis nipa modulating awọn ipa ọna ifihan agbara. bii AKT, NF-κB ati FOXO3.O tun le ṣe idiwọ ikosile jiini ti estrogen-induced ati fa aapọn reticulum endoplasmic.chemicalbookDIM le paarọ iṣelọpọ estrogen ati atako estrogen ati iṣẹ olugba androgen.Ninu awọn ijinlẹ vivo ti fihan pe DIM munadoko lodi si itankalẹ eto lẹhin awọn iṣakoso pupọ.Ninu awọn idanwo vivo, DIM pese aabo itankalẹ tabi idinku.Ni awọn ara deede, DIM mu ATM ṣiṣẹ.dIM le ṣe abojuto si awọn eku nipasẹ kikun ẹnu (250 mg / kg) pẹlu bioavailability giga ati pe ko si t

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