Awọn ọja
Bucladesine
Ilana Ilana
Ti ara Properties
Irisi: White ri robi ọja
Ipo ipamọ: -20°C
Solubility H2O: 50 mg/ml
Data Abo
O jẹ ti awọn ọja ti o wọpọ
Ohun elo
Dibutyryl cyclic adenosine monophosphate sodium jẹ itọsẹ ti adenosine monophosphate cyclic, eyiti a lo lati ṣe itọju mọnamọna cardiogenic ati ikuna ọkan.Ni 1999, Dibutyryl cyclic adenosine monophosphate sodium ikunra ti ni idagbasoke lati ṣe itọju ikolu awọ-ara ati ọgbẹ ara.
Igbaradi ti iṣuu soda dibutyryl cyclophosphate adenosine: Ninu flask ti o ni cyclophosphate adenosine laiyara ṣafikun ojutu iṣuu soda hydroxide olomi (3 mol / L) dropwise, iwọn otutu iṣakoso ilana, fifẹ ti pari imorusi si iwọn otutu yara, ṣatunṣe pH si 7 ~ 8 pẹlu ojutu HCl ( 20%), ṣafikun ojoriro ethanol anhydrous ti funfun ti o lagbara, sisẹ, gbigbe lati gba iyọ iṣuu soda funfun kan;iyọ iṣuu soda ati n-butyl anhydride labẹ aabo ti imorusi N2 si iṣesi 140 ℃.Abojuto TLC, iṣesi naa ti pari ati lẹhinna lọ silẹ si iwọn otutu yara, laiyara ṣafikun methyl tert-butyl ether, ilana ti aruwo ti o lagbara, Iwe-kemikali lati gba ọja robi funfun ti o fẹẹrẹ fẹẹrẹ.Adalu methyl tert-butyl ether ati acetone ti tun daduro lati gba ọja ibi-afẹde funfun kan.Iṣẹ ṣiṣe ti ibiDibutyryl-cAMP (Bucladesine, dbcAMP) jẹ oluṣe PKA ti o le gba sẹẹli ti o ṣiṣẹ nipasẹ ṣiṣefarawe cAMP endogenous.Dibutyryl-cAMP(Bucladesine) tun jẹ oludena phosphodiesterase (PDE).
Awọn ẹkọ inu vitro:Dibutyryl-cAMP ṣe idiwọ gbigba glukosi neuronal nipasẹ imuṣiṣẹ PKA.Ninu awọn hepatocytes eku ti aṣa, Dibutyryl-cAMP ṣe idiwọ ikosile nitric oxide synthase inducible ati iṣẹ abuda NF-kappaB.dibutyrChemicalbookyl-cAMP tun ṣe idiwọ apoptosis sẹẹli ọpá ti TNFalpha nipasẹ didaduro imuduro FADD.
Ninu awọn ẹkọ vivo: Ninu awoṣe Asin, Bucladesine (600nM/Asin, ip) yiyipada zinc kiloraidi ati asiwaju acetate fa ailagbara idaduro iranti evasive.
